Cardiac and vascular effects of atrial natriuretic factor and sodium nitroprusside in healthy men.

• DOI: 10.1161/01.cir.79.2.383
• Publication Date: 2011-06-17T20:29:13Z
• Authors: L F Roy; R I Ogilvie; P Larochelle; P Hamet; F H Leenen
• Keywords: Sodium nitroprusside; Cardiac index

To assess the contribution of venous effects to hemodynamic changes caused by atrial natriuretic factor (ANF), cardiac and peripheral ANF were compared with those induced venoarterial vasodilator sodium nitroprusside. On 3 different days, eight healthy subjects received 2-hour infusions either ANF, nitroprusside, or placebo, a single-blind crossover design. was administered at rate 15 ng/kg/min for hour 1 50 2; each infusion preceded 50-micrograms bolus. The lower increased plasma cGMP fourfold, but only modest cardiovascular (small decreases in left ventricular end-diastolic end-systolic volumes) noted. At higher rate, volumes intravascular volume, as indirectly assessed hematocrit levels, decreased further, which resulted stroke index, systolic blood pressure. No evidence arterial vasodilation (no decrease diastolic pressure, total resistance, forearm resistance) obtained, no increase sympathetic activity In contrast, nitroprusside vasodilation, an significant increases activity. We conclude that short-term within physiologic range primarily affect vascular bed (by decreasing volume venodilation) without increasing