Diastolic Dysfunction in Hypertensive Heart Disease Is Associated With Altered Myocardial Metabolism

• DOI: 10.1161/01.cir.99.17.2261
• Publication Date: 2012-06-12T00:42:29Z
• Authors: Hildo J. Lamb; Hugo P. Beyerbacht; Arnoud van der La...; Berend C. Stoel; Joost Doornbos; Ernst E. van der ...; Albert de Roos
• Keywords: Hypertensive heart disease; Dobutamine

Hypertension is an important clinical problem and often accompanied by left ventricular (LV) hypertrophy dysfunction. Whether the myocardial high-energy phosphate (HEP) metabolism altered in human hypertensive heart disease whether this associated with LV dysfunction not known.Eleven patients hypertension 13 age-matched healthy subjects were studied magnetic resonance imaging at rest phosphorus-31 spectroscopy during high-dose atropine-dobutamine stress. Hypertensive showed higher mass (98+/-28 g/m2) than control (73+/-13 g/m2, P<0.01). filling was impaired patients, reflected a decreased peak rate of wall thinning (PRWThn), E/A ratio, early rate, deceleration (all P<0. 05), whereas systolic function still normal. The phosphocreatine (PCr)/ATP ratio determined (1. 20+/-0.18) stress (0.95+/-0.25) lower corresponding values obtained from (1.39+/-0.17, P<0.05) (1.16+/-0.18, P<0.05). PCr/ATP correlated significantly PRWThn (r=-0.55, P<0.01), (r=-0.56, rate-pressure product (r=-0.53, P<0.001).Myocardial HEP disease. In addition, there association between diastolic humans. level most likely cardiac work load.