Renin-angiotensin and adrenergic mechanisms in control of blood pressure in fowl.

• DOI: 10.1161/01.hyp.3.3_pt_2.i41
• Publication Date: 2013-09-05T12:38:51Z
• Authors: H Nishimura; Y Nakamura; A A Taylor; M A Madey
• Keywords: Plasma renin activity; Fowl

Many avian species demonstrate atherosclerosis and high blood pressure (BP) that are influenced by age, sex, diet, environment, but show no arteriosclerosis in small vessels. Thus, we aimed to define neural humoral control of BP conscious, 32-wk-old female chickens, Gallus gallus. Mean aortic (determined chronically implanted catheter) was 137.6 +/- 2.0 mm Hg; heart rate 295 4 beats/min. Plasma renin activity (PRA), measured radioimmunoassay fowl angiotensin I ([Asp1, Val5, Ser9]AI), plasma angiotensinogen levels were 3.55 0.31 ng/ml/hr 1229 66 ng/ml respectively. Repeated injection propranolol (4 8 mg/kg/day, i.m.) decreased (p less than 0.01) the 19.1 3.0 Hg 76 6 Acute infusion also markedly reduced rate, increased norepinephrine epinephrine. SQ 14,225 (20 mg/kg/day) 0.01), returned towards original unless a higher dose given. PRA 2- 6-fold. 31.0 2.1 after reserpine treatment, not [Sar1, Ile8]AII. These results suggest maintaining beta-adrenergic function is important, whereas renin-angiotensin system may have primary role.