Responses of the heart to stimulation of aortic body chemoreceptors in dogs.

• DOI: 10.1161/01.res.46.1.77
• Publication Date: 2012-06-12T00:17:09Z
• Authors: F Karim; R Hainsworth; O A Sofola; L M Wood
• Keywords: Aortic pressure; Chloralose; Carotid sinus

We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing isolated arch venous blood. Inotropic responses determined measuring maximum rate of change left ventricular pressure (dP/dt max) heart held constant. Stimulation resulted an average increase 14 +/- 2.0 beats/min (mean SE) from 166 7.7 dP/dt max 501 85 mm Hg/sec 3508 154 Hg/sec. These changes statistically significant (P less than 0.001). The afferent pathway reflex was shown to be vagus nerves efferent cardiac sympathetic nerves. In some dogs, carotid also stimulated. This decreases 48 24 795 142 Thus we have stimulation evokes chronotropic inotropic opposite those evoked chemoreceptors.