Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function.

• DOI: 10.1161/01.res.49.3.618
• Publication Date: 2012-06-12T00:17:09Z
• Authors: P J Fletcher; J M Pfeffer; M A Pfeffer; E Braunwald
• Keywords: Ventricular pressure

To determine the effects of healed myocardial infarction on diastolic compliance left ventricle, we studied 36 rats 26 days after coronary artery ligation. Peak cardiac output and stroke volume were measured under ether anesthesia during loading, peak ventricular developed pressure was determined occlusion ascending aorta. During a slow infusion saline into potassium-arrested continuously over range -5 to 30 mm Hg. Infarct size by planimetry serial sections taken from each heart at 1-mm intervals apex base. In with infarcts, increased in proportion infarct pressure-volume relationship shifted so that pressures below 2.5 Hg increased, resulting an this low range. Above pressure, slopes curves similar without infarctions. pressure-generating capacity impaired size. This impairment performance correlated size-related increase volume, which served offset reduction flow generating caused systolic dysfunction, while contributing directly capacity.