Nonhypertensive Cerebral Small-Vessel Disease

• DOI: 10.1161/01.str.28.11.2222
• Publication Date: 2011-06-17T20:08:03Z
• Authors: G. Alistair Lammie; Frances Brannan; Jim Slattery; Charles Warlow
• Keywords: Fibrinoid necrosis; Leukoaraiosis; Hyaline

Background and Purpose Cerebral small-vessel disease (SVD) is a common aging phenomenon that exacerbated by hypertension diabetes mellitus. It regarded as an important cause of lacunar infarction intracerebral hemorrhage. The present study was performed to highlight the existence some extent frequency pathologically verified SVD lacking in classic risk factors extend scope factor analysis. Methods group comprised 70 consecutively referred autopsy brains with microscopic evidence SVD. In each case clinical records, reports, central nervous system systemic histology were reviewed. graded mild, moderate, or severe six standardized brain regions, results analyzed relation presence absence factors. Results manifest largely concentric hyaline wall thickening; lipohyalinosis fibrinoid necrosis rarely observed. Thirty-one percent cases failed meet stringent clinicopathological criteria for significant prior hypertension. 9% cases, patients had been nonelderly, nondiabetic, normotensive. Five conditions known enhance permeability. Conclusions nature appears have modified effective treatment Classic are often absent. hypothesis variety permeability may contribute pathogenesis merits consideration.