Polymorphism in the Promoter of Lipopolysaccharide Receptor CD14 and Ischemic Cerebrovascular Disease

• DOI: 10.1161/01.str.31.11.2661
• Publication Date: 2011-06-17T20:08:03Z
• Authors: Daisuke Ito; Mitsuru Murata; Norio Tanahashi; Hideki Sato; Akira Sonoda; Ikuo Saito; Kiyoaki Watanabe; Yasuo Fukuuchi
• Keywords: Male; Polymorphism, Genetic; Lipopolysaccharide Receptors; Middle Aged; Cerebrovascular Disorders; 03 medical and health sciences; 0302 clinical medicine; Japan; Risk Factors; Humans; Female; Promoter Regions, Genetic

Background and Purpose —A growing amount of evidence suggests that infectious inflammatory processes may be involved in the initiation arteriosclerosis, but mechanisms are conceivably multifactorial complex. Two European groups have recently demonstrated a C(−260)→T polymorphism promoter CD14 lipopolysaccharide receptor risk factor for coronary artery disease (CAD). The T allele this reportedly increases expression atherogenesis. In present study we investigated possible association between occurrence symptomatic ischemic cerebrovascular (CVD). Methods —Genotype frequencies were determined 235 patients with CVD, as confirmed by brain CT and/or MRI, 309 age- sex-matched control subjects. Results —The distribution genotypes was follows: CVD patients, / 24.3%, C 53.2%, 22.6%; controls, 26.9%, 50.2%, 23.0%. There no significant difference controls (χ 2 =0.601, P =0.741). We also measured concentration serum soluble density membranous on monocytes not associated either or ( =0.358, =0.238, respectively). Conclusions —Our results indicate is an increased CVD.