Vasospasm in Monkeys Resolves Because of Loss of and Encasement of Subarachnoid Blood Clot

• DOI: 10.1161/01.str.32.8.1868
• Publication Date: 2011-06-17T20:08:03Z
• Authors: Zhen-Du Zhang; Baktair Yamini; Taro Komuro; Shigeki Ono; Lydia Johns; Linda S. Marton; Bryce Weir; R. Loch Macdonald
• Keywords: Cerebral Vasospasm; Clot formation

Background and Purpose — We studied in monkeys why vasospasm resolves after subarachnoid hemorrhage (SAH). Methods Monkeys underwent angiography right (n=17) or bilateral (n=8) SAH. Animals with SAH 1, 3, 5, 7 days later. The clot was then not removed (n=5), replaced fresh (n=7), (n=5). At the same time on day 7, (n=12) (n=5) placed left side. Angiography repeated every 2 until 14. Results caused significant that resolved by Removal of resulted more rapid resolution vasospasm. Placement onto arteries had already been exposed to for produced persisted without resolving an additional days. 7-day-old from previously unexposed blood animal significantly onset compared de novo Microscopic examination clots showed they were surrounded macrophages Arterial compliance contractility reduced relation duration exposure clot. Conclusions Vasospasm because loss hypothesize spasmogen release contributes There no response cerebral rendered them less responsive