Blood coagulation and plasma fibrinolytic enzyme system pathophysiology in stroke.

• DOI: 10.1161/01.str.7.4.337
• Publication Date: 2011-06-17T20:10:52Z
• Authors: A P Fletcher; N Alkjaersig; A Davies; M Lewis; J Brooks; W Hardin; W Landau; M E Raichle
• Keywords: Stroke; Pathophysiology

Plasma fibrinogen chromatography is a method for quantification of high molecular weight complexes (HMWFC), native and other derivatives in plasma. Enchanced formation fibrin, intravascular coagulation, thrombus formation, etc., are reflected by elevation plasma HMWFC, the distinguishes between subjects with normal pathological rates fibrin formation. Serial standard blood coagulation assays, including chromatography, neurological studies were performed on 220 patients admitted to stroke unit. Findings from cerebral infarction compared against those three control groups: (1)normals, (2)a group and(3)a risk factor group. HMWFC findings significantly (p less than 0.001) higher normals. values any groups, fibrinogen, plasminogen, alpha1-antitrypsin alpha2-macroglobulin also significiantly patients. The greater degree initial deficit, 0.001), associated poor clinical outcome. intracerebral hemorrhage, subarachnoid hemorrhage embolism. These docunment fact that proportion have coagulopathy, characterized enhancement