Abstract 588: Glyc-A, a Novel Inflammatory Biomarker, is Associated With Total and Non-Calcified Coronary Plaque Burden Beyond Traditional Cardiovascular Risk Factors

• DOI: 10.1161/atvb.36.suppl_1.588
• Publication Date: 2021-06-21T16:58:35Z
• Authors: Aditya A Joshi; Joseph B Lerman; Tsion M Aberra; Mohammad Tarek Ka...; Heather L Teague; Joanna I Silverman; Qimin Ng; Tarek Z Aridi; Yvonne Baumer; Taufiq S Salahuddin; Marcus Y Chen; David A Bluemke; Justin Rodante; Joel M Gelfand; Martin P Playford; Nehal N Mehta

Introduction: Recent studies suggest that hsCRP may inaccurately predict coronary heart disease (CHD) in patients with chronic inflammatory disorders. GlycA, a novel biomarker measured by nuclear magnetic resonance, was associated future cardiovascular events large cohort study. Whether GlycA predicts CHD beyond is unknown. Psoriasis (PSO), increased risk, provides clinical human model to assess the utility of as risk marker CHD. Hypothesis: We hypothesized would associate CHD, total (TB) and non-calcified burden (NCB) assessed CT angiography, traditional factors PSO. Methods: 151 consecutive PSO 40 controls underwent angiography (320 detector row) part study (NCT01778569). Coronary plaque QAngio (Medis). resonance (LabCorp). A physician ascertained parameters. Labs were certified research facility. Statistical analyses include multivariate regression ROC modeling. Results: older, at low Framingham but had significant cardiometabolic dysfunction TB NCB (Table). While significantly controls, it showed no relationship however, strongly (β=0.14, p=0.01) (β=0.12, Finally, demonstrated greater AUC for predicting (Figure), suggesting adds incremental value factors. Conclusion: In conclusion, associates Our suggests role assessing states. Larger prospective are needed confirm these findings.