VEGFR1 Tyrosine Kinase Signaling Promotes Lymphangiogenesis as Well as Angiogenesis Indirectly via Macrophage Recruitment

• DOI: 10.1161/atvbaha.107.150433
• Publication Date: 2008-01-04T01:55:16Z
• Authors: Masato Murakami; Yujuan Zheng; Masanori Hirashima; Toshio Suda; Yohei Morita; Jun Ooehara; Hideo Ema; Guo-Hua Fong; Masabumi Shibuya
• Keywords: Lymphangiogenesis

Angiogenesis and lymphangiogenesis are complex phenomena that involve the interplay of several growth factors receptors. Recently, we have demonstrated in Keratin-14 (K14) promoter-driven Vegf-A transgenic (Tg) mice, not only angiogenesis but also is stimulated. However, mechanism by which VEGFR1 involved remains unclear.To examine how important tyrosine kinase (TK) K14 Tg crossed mice with VEGFR1-TK-deficient to generate double mutant Vegfr1 tk(-/-) mice. exhibit a remarkable decrease lymphangiogensis as well subcutaneous tissues. To address underlying lymphangiogensis, investigated recruitment monocyte-macrophage-lineage cells into skin. The VEGFR1-expressing macrophages driven VEGF-A was reduced received bone marrow showed reduction macrophage recruitment, compared those mice.VEGFR1 signaling promotes mainly increasing marrow-derived recruitment.