Gene Expression Signatures of Coronary Heart Disease

• DOI: 10.1161/atvbaha.112.301169
• Publication Date: 2013-03-29T05:42:11Z
• Authors: Roby Joehanes; Saixia Ying; Tianxiao Huan; Andrew D. Johnson; Nalini Raghavachari; Richard Wang; Poching Liu; Kimberly A. Woodh...; Shurjo K. Sen; Kahraman Tanriverdi; Paul Courchesne; Jane E. Freedman; Christopher J. O’...; Daniel Levy; Peter J. Munson
• Keywords: Framingham Heart Study

Objective— To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and age- sex-matched controls who were participants the Framingham Heart Study. Approach Results— A total 35 genes differentially expressed versus at false discovery rate<0.5, including GZMB , TMEM56 GUK1 . Cluster analysis revealed 3 gene clusters associated CHD, 2 linked to increased erythrocyte production a third reduced natural killer T cell activity CHD. Exon-level results corroborated extended gene-level results. Alternative splicing suggested that 38 other spliced controls. Gene Ontology ubiquitination T-cell–related pathways Conclusions— Two bioinformatically defined groups show consistent associations Our findings are hypotheses hematopoesis is upregulated possibly reflecting compensatory mechanism, innate immune disrupted or altered by its treatment. Transcriptomic signatures may be useful identifying point toward novel therapeutic targets for treatment prevention.