Role of SN1 Lipases on Plasma Lipids in Metabolic Syndrome and Obesity

• DOI: 10.1161/atvbaha.113.303027
• Publication Date: 2014-01-24T04:58:21Z
• Authors: Verónica Miksztowicz; Laura Schreier; Mary McCoy; Diego Lucero; Eduardo Fassio; Jeffrey Billheimer; Daniel J. Rader; Gabriela Berg
• Keywords: Adult; Male; Lipoproteins; Fatty Acids, Nonesterified; Body Mass Index; 03 medical and health sciences; 0302 clinical medicine; https://purl.org/becyt/ford/3.3; Humans; Lipg Protein; https://purl.org/becyt/ford/3; Obesity; Triglycerides; Metabolic Syndrome; 2. Zero hunger; Apolipoprotein A-I; Metabolic Syndrome X; Cholesterol, HDL; Cholesterol, LDL; Lipase; Middle Aged; Overweight; Hepatic Lipase; Lipids; 3. Good health; Lipoprotein Lipase; Phospholipases; Female; Insulin Resistance; Human

Objective— To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma subjects with metabolic syndrome (MS)/obesity their relationship atherogenic antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein (LPL) HL as triglyceride (TG)-hydrolyses complete analyses SN1 lipolytic enzymes same patient. Approach Results— Plasma EL, HL, LPL activities were evaluated 59 patients MS 36 controls. A trend toward higher EL was observed MS. increased obese compared normal weight group ( P =0.009) negatively associated high-density lipoprotein–cholesterol =0.014 =0.005) apolipoprotein A-I =0.045 =0.001) control group, respectively. activity, TG-hydrolase, =0.025) well =0.017); directly correlated low-density B =0.003) =0.021) group. decreased <0.001) overweight =0.015 =0.004, respectively); inversely %TG-very lipoproteins =0.04) TG/apolipoprotein index =0.013) These associations not found Conclusions— We describe for first time phospholipases MS/obesity, being both responsible catabolism. Our results elucidate part remaining controversies about lipases different grades obesity. The impact insulin resistance on 3 determines alterations these states.