MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering

• DOI: 10.1161/atvbaha.117.310211
• Publication Date: 2018-01-25T10:00:13Z
• Authors: Xiao Huang; Xianhui Qin; Wenbin Yang; Lishun Liu; Chongfei Jiang; Xianglin Zhang; Shanqun Jiang; Huihui Bao; Hai Su; Ping Li; Mingli He; Yun Song; Min Zhao; Delu Yin; Yu Wang; Yan Zhang; Jianping Li; Renqang Yang; Yanqing Wu; Kui Hong; Qinhua Wu; Yundai Chen; Ningling Sun; Xiaoying Li; Genfu Tang; Binyan Wang; Yefeng Cai; Fan Fan Hou; Yong Huo; Hong Wang; Xiaobin Wang; Xiaoshu Cheng
• Keywords: Male; China; Time Factors; Genotype; Hyperhomocysteinemia; Blood Pressure; Middle Aged; 3. Good health; 03 medical and health sciences; Folic Acid; Treatment Outcome; 0302 clinical medicine; Double-Blind Method; Enalapril; Hypertension; Vitamin B Complex; Humans; Female; Homocysteine; Antihypertensive Agents; Biomarkers; Methylenetetrahydrofolate Reductase (NADPH2); Aged

Objective— This post hoc analysis of the CSPPT (China Stroke Primary Prevention Trial) assessed individual variation in total homocysteine (tHcy)–lowering response after an average 4.5 years 0.8 mg daily folic acid therapy Chinese hypertensive adults and evaluated effect modification by methylenetetrahydrofolate reductase ( MTHFR ) C677T genotypes serum folate levels. Approach Results— included 16 413 participants from CSPPT, who were randomly assigned to 2 double-blind treatment groups: either 10-mg enalapril+0.8-mg or enalapril, had measurements tHcy levels at baseline exit visits genotypes. Mean comparable between groups (14.5±8.5 versus 14.4±8.1 μmol/L; P =0.561). After treatment, mean reduced 12.7±6.1 μmol/L enalapril+folic group, but almost stayed same enalapril group (14.4±7.9 μmol/L, difference: 1.61 11% reduction). More importantly, lowering varied Compared with CC CT genotypes, TT genotype a more prominent L-shaped curve required higher (at least 15 ng/mL) eliminate differences Conclusions— CT, manifested heightened low high levels, this difference was eliminated when plasma reach ≈15 ng/mL higher. Our data raised prospect tailor according status. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00794885.