Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen—Brief Report

• DOI: 10.1161/atvbaha.122.318930
• Publication Date: 2023-06-22T10:50:00Z
• Authors: Naofumi Amioka; Chia-Hua Wu; Hisashi Sawada; Sohei Ito; Alex C. Pettey; Congqing Wu; Jessica J. Moorle...; Deborah A. Howatt; Gregory A. Graf; Craig W. Vander Kooi; Alan Daugherty; Hong S. Lu
• Keywords: Male; Glycosylation; Angiotensinogen; Atherosclerosis; Endoplasmic Reticulum; 3. Good health; Renin-Angiotensin System; Mice; Liver; Hepatocytes; Animals; Female; Protein Conformation, beta-Strand; Amino Acid Sequence; Conserved Sequence

Angiotensinogen (AGT) is an essential component in the renin-angiotensin system. AGT has highly conserved sequences loop and β-sheet regions among species; however, their functions have not been studied.