Abstract 18379: Echocardiography for Right Ventricular Failure Prediction After Implantation of Left Ventricular Assist Devices: Preliminary Results From a Prospective Cohort Study

• DOI: 10.1161/circ.128.suppl_22.a18379
• Publication Date: 2024-04-23T10:56:54Z
• Authors: Andreas P Kaloger...; Vasiliki V Georgi...; Sarawut Siwamogsa...; Daniel Sims; Anita Kelkar; Kris Wittersheim; Ann Pekarek; Maria A Pernetz; Duc Q Nguyen; Andrew L Smith; J David Vega; Javed Butler
• Keywords: Right ventricular failure; Ventricular Function

Background: Right ventricular failure (RVF) occurs in 20%-40% of left assist device (LVAD) recipients. Preoperative clinical scores inadequately predict RVF risk these patients. Methods: Beginning 6/2012, all adults with INTERMACS ≥2 profile scheduled for LVAD implantation, without planned right (RV) support, were prospectively enrolled an ongoing study evaluating standard and speckle-tracking echocardiographic parameters RV function prediction. echocardiograms performed 5±5 days prior to implantation by protocol. The primary endpoint was RVF, defined (by INTERMACS) as need (1) inotropes or pulmonary vasodilators any time past 7 post-LVAD implant concomitant high central venous pressure low cardiac index (2) mechanical support. secondary death from cause. Results: As 5/2013, 26 patients have been enrolled. Table 1 summarizes the preoperative hemodynamic characteristics. At 30 days, (26.9%) developed 3 (11.5%) died. Intensive care length stay (LoS) 8.0±3.6 total LoS 16.3±9.5 days. Among (Table 2), global longitudinal strain (GLS) strongest predictor a C statistic 0.86 (95% CI, 0.60-0.99). cut-off -6.0%, sensitivity specificity 86% 79%, respectively. Similarly, GLS combined. Standard weak outcome predictors. Conclusion: parameters, speckle tracking appears be RVF.