Abstract 15530: Omega-3 Fatty acids Supplementation Attenuates the Progression of Microalbuminuria in Diabetics With Coronary Artery Disease

• DOI: 10.1161/circ.132.suppl_3.15530
• Publication Date: 2021-07-03T04:10:04Z
• Authors: Dharshan K Lakshm...; Tarec K Elajami; Michael Soliman; Abdulhamied Alfad...; Francine K Welty
• Keywords: Microalbuminuria; Albuminuria

Introduction: Microalbuminuria is a marker of generalized endothelial dysfunction, key step in the pathogenesis coronary artery disease (CAD). It also an independent predictor cardiovascular morbidity and mortality. Angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy considered standard care to attenuate progression albuminuria diabetic patients. Hypothesis: Omega-3 fatty acids (FAs) supplementation will microalbuminuria subjects with stable CAD. Method: In our study, 262 CAD were randomized 3.6 g omega-3 FAs (1.86 eicosapentaenoic acid + 1.5 docosahexaenoic acid) per day no FA (control) for one year. Urine microalbumin creatinine ratio (urine MCR mg/g) was calculated as measure at baseline year follow-up. Results: Mean age 63.3 ± 7.6 yrs, 17% women, 30% had diabetes, 74% on ACEI ARB therapy. At follow-up non-diabetics, there significant difference % change urine between control groups (see table). contrast diabetics, those not receiving 72.3% increase whereas (table). subgroup analysis, diabetics 64.2% Conclusions: attenuated worsening compared over period. Our results suggest that combination better attenuating than alone This suggests may provide additional benefit when added ACEI/ARB