Abstract P228: Lower Serum 25-hydroxyvitamin D Concentration is Associated With Greater Risk of Non-alcoholic Fatty Liver Disease Among Caucasians but Not Other Racial-ethnic Groups in the Multi Ethnic Study of Atherosclerosis

• DOI: 10.1161/circ.135.suppl_1.p228
• Publication Date: 2021-07-03T02:29:11Z
• Authors: Samar R El Khoudary; Saad Samargandy; Irfan Zeb; Temitope Foster; Ian De Boer; Dong Li; Matt Budoff
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 16. Peace & justice; 3. Good health

Objective: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic in developed nations and independently associated with increased overall morality from all causes as well CVD. Growing evidence support that low serum 25-hydroxyvitamin D ((25OH)D) NAFLD. However, significant racial/ethnic differences exist 25(OH)D prevalence NAFLD: African Americans have lower than Caucasians, NAFLD higher Caucasians. We tested whether association between vary by race/ethnicity, adjusting for common risk factors Methods: Participants were MESA study, who free CVD conditions, not taking oral corticosteroids, did report heavy alcohol intake (>7 drinks/week women > 14 men), had upper abdominal non-contrast CT images available at baseline. was adjusted season. defined if liver-to-spleen Hounsfield units ratio <1. Logistic regression used statistical analyses. Final models study site, age, gender, education, income, BMI, triglycerides, high-density lipoproteins, systolic blood pressure, smoking, diabetes, interlukine-6 C-reactive protein. Results: The included3,484 participants (mean age (SD): 62.7(10.4) Yr; 44% male; 38.4% Caucasian, 27.8% American, 23.5% Hispanic, 10.3% Chinese American). Serum significantly varied race/ethnicity; Caucasian highest levels American lowest (mean(SD): 29.5(10.4)ng/ml vs. 19.6(9.1)ng/ml, respectively, p<0.0001). present among 17.5% (n=611) participants; Hispanic showing rate (26.2%) followed (19.8%), (15.8%) (11.7%), P=<0.0001. In unadjusted final models, differed race/ethnicity (P<0.01). Stratification analyses showed negative only Causations; such (adjusted OR (95% CI):1.23(1.03, 1.47) per 1 SD decrease 25(OH)D). For other groups, diabetic status and/or but 25(OH)D, independent Conclusions: varies race/ethnicity. Future studies should assess targeting vitamin deficiency Caucasians may reduce their above beyond controlling modifiable factors, whereas, excluding D, be more important reducing groups.