Abstract 13174: Female Sex is Not Associated With Subsequent Heart Failure in Adult Patients Treated With Anthracyclines

• DOI: 10.1161/circ.144.suppl_1.13174
• Publication Date: 2024-04-23T13:44:06Z
• Authors: Gabriel Pajares H...; Andrea Nathalie R...; Cole Turissini; Sujithraj Dommaraju; Sarah Warack; Michelle J Keyes; Jordan B Strom; Aarti Asnani
• Keywords: Female sex

Introduction and Hypothesis: Female sex has long been considered a risk factor for anthracycline-associated cardiotoxicity, based largely on data in childhood cancer survivors. However, preclinical experiments suggest that female hormones present adulthood may protect against doxorubicin cardiotoxicity. We therefore hypothesized would be associated with decreased odds of heart failure adult patients treated anthracyclines. Methods: conducted retrospective cohort study 871 (44% women 56% men) at our medical center no prior history who were anthracyclines non-hormone-dependent malignancies including lymphoma, leukemia, sarcoma. Patients expired during the period excluded. The presence or absence within five years initiation was assessed using ICD-9/10 codes. Logistic regression models used to assess ratios self-reported other covariates, adjusting age. Results: Baseline characteristics similar men women, age, total cumulative anthracycline dose, prevalence cardiovascular comorbidities such as hypertension, diabetes, coronary artery disease. increased modestly age (OR: 1.02; 95% CI: 1.01 1.03, p = 0.001). In an age-adjusted model, not subsequent CI 0.72 1.47, 0.88), after stratification by ≤ 50 > surrogate menopausal status. Conclusions: this study, tumors. These findings diverge from reports suggesting cardiotoxicity women. Future studies will competing risks disease/death versus