Abstract 13183: Persistent Anemia Was Associated With Higher Long-Term Mortality in Patients With Chronic Kidney Disease Following Primary Percutaneous Coronary Intervention

• DOI: 10.1161/circ.144.suppl_1.13183
• Publication Date: 2024-04-23T13:44:06Z
• Authors: Takuma Koike; Yuichi Chikata; Hiroshi Iwata; Hidetoshi Yasuda; Takehiro Funamizu; Shinichiro Doi; Jun Shitara; Hirohisa Endo; Hideki Wada; Ryo Naito; Manabu Ogita; Tomotaka Dohi; Takatoshi Kasai; Shinya Okazaki; Katsumi Miyauchi; Hiroyuki Daida; Tohru Minamino

Background: Anemia is one of the most common complications chronic kidney disease (CKD), renal anemia, which has a significant link with increased risk morbidity, as well mortality cardiovascular disease. However, prognostic implication temporal change anemia status been rarely addressed, especially in secondary prevention coronary artery (CAD). Methods and Results: This long-term (median follow-up range: 5.7 years) single center observational study involved consecutive 416 patients CKD over stage 3 (defined by eGFR<60 ml/1.72/m 2 ) who underwent percutaneous intervention (PCI) for first time since 2003 to 2018. All-cause death was set an endpoint. Participants were divided into 4 groups median hemoglobin (Hb) at PCI (baseline, 12.0 mg/dl) 8.1±2.1 months after (follow-up, 12.7 mg/dl), respectively: Groups Continuously high-Hb (n=146), Increased-Hb (n=51), Attenuated-Hb (n=61) Persistently low-Hb (n=158). Categorized Cox proportional hazard analysis setting group reference showed significantly all-cause Attenuated- (Hazard ratio (HR) 2.6, 95% confidence interval (CI) 1.3-5.2, p=0.01) (HR 95%CI 1.4-4.8, p=0.002), respectively, while similar 1.1, 0.3-3.2, p>0.5) (Figure) . Conclusion: association between reduced Hb overtime CAD, might potentially indicate merit this population.