Abstract 14343: Predictive Value of Myocardial Strain for Chimeric Antigen Receptor T-cell Therapy Associated Cardiovascular Events

• DOI: 10.1161/circ.144.suppl_1.14343
• Publication Date: 2024-04-23T14:34:58Z
• Authors: Nikita Patel; Prarthana Dalal; Gregory Cascino; Arjun Sinha; Ashwin Sunderraj; Matthew Feinstein; Nausheen Akhter
• Keywords: Strain (injury); Value (mathematics)

Introduction: Cardiovascular events following Chimeric Antigen Receptor (CAR) T-cell therapy are increasingly recognized. Left ventricular systolic dysfunction and arrhythmias the most common cardiac toxicities seen. Thus, risk stratification in this population is important, especially adults with subclinical disease. Although left global longitudinal strain (LV-GLS) has demonstrated prognostic utility for other cancer related dysfunction, less known regarding predictors of adverse CAR therapy. We determined association baseline LV-GLS cardiovascular receiving CAR-T cell Methods: identified 75 patients who had measurements available within 6 months initiating at a large urban medical center from 2016-2020. Demographics, malignancy history, treatment data, factors, echocardiographic (LV-GLS ejection fraction (LVEF)), were retrospectively collected via chart review. Absolute value was used ease interpretation. Multivariable logistic regression to determine (per 1% rise) adjustment age, BMI, CAD, HTN, HLD, DM, previous cardiotoxic chemotherapy. Results & Conclusions: There 10 therapy-related events, including 1 death, 3 new/worsening cardiomyopathies, arrythmias. Higher rise absolute value) associated significantly lower (OR 0.66, 95% CI 0.46, 0.96). These findings suggest may risk-stratify toxicity. Additional prospective studies cohorts needed corroborate these findings.