Abstract 010: Longitudinal Impact Of Glucose Homeostasis On Cardiac Structure And Function: Results From The Echocardiographic Study Of Latinos- 2 (echo-sol-2)

• DOI: 10.1161/circ.145.suppl_1.010
• Publication Date: 2022-04-07T15:49:21Z
• Authors: Patricia Chavez; Ayana K April-San...; Un Jung Lee; Jianwen Cai; Sonia Ponce; Matthew A Allison; Gregory A Talavera; Mayank M Kansal; Martha L Daviglus; Robert Ostfeld; Neil Schneiderman; Daniela Sotres-Al...; Leonor Corsino; Carlos Rodriguez
• Keywords: Prediabetes; Homeostasis; Blood sugar regulation; Fasting glucose

Introduction: We assessed whether a longitudinal association between change in glucose homeostasis and cardiac structure function was present. Methods: Data from ECHO-SOL baseline visit 2 exams were used including 1643 Hispanic/Latino participants aged 45-74 years with serial echocardiograms obtained on average 4.3 (2.8-6.7) apart. Glucose hoemostasis evaluated through fasting plasma levels (FGP), hour oral tolerance test (OGTT) hemoglobin A1C (A1C) . categorized as: normal (NGT) (FPG<100 mg/dL, 2hr OGTT <140 or <5.7%), prediabetes (PDM) (FPG 100–125 2h 140–199 5.7–6.4%); among those self-report of diabetes currently taking medicine: controlled (CDM) (A1C<7), uncontrolled (UDM) (A1C>7). Linear regression models to examine associations [worsening (NGT PDM, NGT DM, PDM CDM UDM) vs unchanged] changes left ventricular mass (LVM), relative wall thickness (RWT), ejection fraction (EF), global strain (GLS) E’ velocity. All analyses weighted account for the complex survey design. Results: At (mean age 56.4 ±0.35; 45.4% male), regulation as follows: (29.1%), (51.8%), (9.2%) UDM (9.9%). 2, downregulation (55.9%), DM (13.4%), (27.4%), UCDM (33.5%). Among worsening 55.2 ±0.50 years, 45.7% male, FPG 99.4±0.90mg/dL Change compared remaining at associated increase LVM (b=4.0 ±0.9, p<0.001), GLS (b=0.6 ±0.1, p<0.001) decrease velocity (b=-1.1 p<0.001). Neither nor significant function. RWT (b=0.1 ±0.0, p<0.05), unchanged CDM. Worsening any group not EF. Conclusions: Early stages structural functional changes. Identification risk developing may provide opportunities prevent future dysfunction.