Abstract EP51: Trends, Predictors And Outcomes Of Cardiovascular Complications Associated With Polycystic Ovary Syndrome During Delivery Hospitalizations-A United States National Database Analysis (2002-2019)

• DOI: 10.1161/circ.145.suppl_1.ep51
• Publication Date: 2022-04-07T15:49:21Z
• Authors: Salman Zahid; Muhammad Z Khan; Smitha Narayana G...; Nadeen N. Faza; Michael Honigberg; Arthur J Vaught; Carolyn Guan; Anum A Minhas; Erin Michos
• Keywords: Dyslipidemia

Background: Women with polycystic ovary syndrome (PCOS) have increased risk of pregnancy-associated complications. However, there is scarcity data on the trends, outcomes, and predictors cardiovascular (CV) complications associated PCOS diagnosis during delivery hospitalizations in United States. Methods Results: We used from National Inpatient Sample. ICD-9 or ICD-10 codes were to identify diagnosis. A total 71,436,308 weighted US for deliveries identified 2002 2019. Of included hospitalizations, 0.3% among women (n=195,675). older (mean 30 vs 28 years, p<0.01) had higher prevalence diabetes, obesity, dyslipidemia. After adjustment age, race/ethnicity, comorbidities, insurance status median household income, remained an independent predictor CV at including preeclampsia (aOR 1.56, 95% CI 1.54-1.59, p<0.01), eclampsia 1.58, peripartum cardiomyopathy 1.79, 1.49-2.13, heart failure 1.76, 1.27-2.45, (Figure, Panel A), compared no PCOS. An increase overall PCOS, obesity those was also observed study period B). Moreover, length (3 2 days, cost hospitalization ($6,310 $4,468, p<0.01). Conclusions: Over a 17-year period, childbearing U.S. women. risks preeclampsia/eclampsia, cardiomyopathy, failure, pulmonary edema, venous thromboembolism. hospitalization. Strategies optimize pre-pregnancy cardiometabolic health may be particularly important improve maternal outcomes.