Abstract P099: Fixed-dose Combination Therapy-based Protocol Compared With Nigeria’S National Hypertension Treatment Protocol: Results Of A Cluster Randomized Trial

• DOI: 10.1161/circ.145.suppl_1.p099
• Publication Date: 2022-04-07T15:49:21Z
• Authors: Olutobi Sanuade; Boni Ale; IKECHUKWU ANTHONY...; Tunde Ojo; Grace Shedul; Eugenia Ugwuneji; Nonye Egenti; Kasarachi Omitiran; Rosemary Okoli; Helen Eze; Ada Nwankwo; Lisa Hirschhorn; Aashima Chopra; Jiancheng Ye; Priya Tripathi; Bolanle Banigbe; Namratha Kandula; Mark D Huffman; Dike Ojji
• Keywords: Amlodipine; Fixed-dose combination; Intention-to-treat analysis; Tolerability

Abstract Importance: Out of the >1.2 billion adults with elevated blood pressure globally, treatment (42.5%) and control (20.5%) rates are very low, including in Nigeria, most populous country Africa. A protocol that includes fixed-dose combination (FDC) therapy may improve hypertension more efficiently no increase adverse events compared a standard protocol. Objective: To determine efficacy safety uses FDC for Nigeria’s 2019 National Hypertension Treatment from baseline to 6 months. Design, setting, participants: Cluster randomized (1:1) trial among 60 primary health centers Abuja, stratified by median case load rate. Eligible patients were ( > 18 years) who had history hypertension, persistently (SBP ≥140 mmHg or DBP ≥90 mmHg),or use lowering medications. Interventions: Sites started utilized 2- 3-drug (Step 1: amlodipine 5 mg + losartan 50 mg) monotherapy added individuals Results: Sixty sites, 5,576 (mean [SD] age=49.2 [12.4] years; 70% female; mean systolic/diastolic BP=155[SD]/96 mm Hg), randomized. At 6-month follow-up, 54.7% 48.3%, respectively Figure 1 ). The final results will be at later date. Conclusion relevance: used led higher rate Nigeria. These have relevance protocols other large-scale programs.