Abstract 15315: Cardiac MRI Tissue Characterization for Intra-Cardiac Thrombi Therapeutic Response in Systemic Cancer Patients

• DOI: 10.1161/circ.148.suppl_1.15315
• Publication Date: 2023-12-19T07:59:21Z
• Authors: Raina Jain; Michael Park; Nicole Liberman; Hannah Agoglia; Jiwon Kim; Richard Steingart; Jennifer Liu; Jonathan W Weinsaft; Angel T Chan
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Introduction: Cardiac MRI (CMR) is often used to identify thrombi (C THR ) based on absence of contrast enhancement but its utility as a predictor of therapeutic response of anticoagulation (AC) is unknown.

Methods: Adult (≥18yo) pts with systemic cancer were matched 1:1 for cancer etiology/stage and presence/absence of C THR on CMR. Cine-CMR assessed cardiac structure/function and localization of C THR . Contrast-enhanced CMR (0.2 mmol/kg gadolinium) was performed for identification of C THR and quantitative tissue properties. C THR resolution was evaluated on serial TTE at a time point of 3 months post CMR; clinical f/u and anticoagulation therapy were determined by chart review.

Results: 189 pts (54±16 yo; 50% M) were studied, 106 with C THR and 83 without. Cancer etiology varied (heme 30%