Abstract P159: Echocardiographic Cardiac Phenotype in Val122Ile Variant Transthyretin Amyloidosis Among Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

• DOI: 10.1161/circ.149.suppl_1.p159
• Publication Date: 2024-05-16T14:05:30Z
• Authors: Ambarish Pandey; Priscilla Duran L...; Katrina Swett; Robert Kaplan; Gregory A Talavera; Martha L Daviglus; Neil Schneiderman; Barry E Hurwitz; Sanjiv J Shah; Tamar Sofer; Scott D Solomon; Susan Cheng; Larissa Aviles-Santa; Humberto Parada; Bharat Thyagarajan; Franklyn Gonzalez; Mayank M Kansal; James M Tauras; Mathew S Maurer; Carlos J Rodriguez
• Keywords: Cardiovascular Health; Cardiac Amyloidosis

Background: Transthyretin amyloidosis, most often caused by Val122Ile mutation, is linked to a higher risk of heart failure (HF) and mortality. Subclinical abnormalities in cardiac structure function mutations are less well defined Hispanics/Latinos. We studied the phenotype Hispanic/Latino carriers versus non-carriers. Methods: carrier status was determined with genome-wide data. analyzed echocardiographic data from adults 45 years or older (unweighted n= 6376) HCHS/SOL Echocardiographic Study Latinos, Echo-SOL. Measures (Table) were compared among non-carriers using age-and-sex-adjusted least square means (continuous variables) proportions (categorical variables). Prevalence pre-HF, identified presence at one abnormal parameter, also those vs. without mutation. Complex survey statistics sample weights utilized for all analyses. Results: (0.8%; unweighted 40) younger (mean ±SE, 55.5 ±1.7), had systolic blood pressure 130 mmHg ±3.6), but lower body mass index 28.5 kg/m 2 ±1.4) than non-carriers, p <0.0001. Lower mean values left ventricle (LV) ejection fraction, LV end diastolic volume, right (RV) fractional area change, lateral peak e’ velocity pre-HF prevalence seen vs mass, worse concentric remodeling, measures Most RV . However, none differences found statistically significant (p >0.05). Conclusion: There lack difference Hispanic/Latinos who carry mutation