Spatiotemporal Organization of the Left Atrial Substrate After Circumferential Pulmonary Vein Isolation of Atrial Fibrillation

• DOI: 10.1161/circep.108.812024
• Publication Date: 2009-03-07T01:59:36Z
• Authors: Yenn-Jiang Lin; Ching-Tai Tai; Tsair Kao; Shih-Lin Chang; Li-Wei Lo; Ta-Chuan Tuan; Ameya R. Udyavar; Wanwarang Wongcha...; Yu-Feng Hu; Han-Wen Tso; Wen-Chin Tsai; Chien-Jung Chang; Kuo-Chang Ueng; Satoshi Higa; Shih-Ann Chen
• Keywords: Isolation; P wave

There is a paucity of data regarding the mechanism maintaining atrial fibrillation (AF) after pulmonary vein isolation (PVI) in patients with AF. The aim this study was to examine impact circumferential PVI on left (LA) substrate characteristics.Seventy-two AF (age, 53+/-11 years) underwent mapping and catheter ablation using an NavX system. biatrial characteristics such as complex fractionated electrograms (CFEs; based intervals) frequency analysis (based dominant frequencies) were mapped before PVI. electric performed all patients. In 45 who did not respond PVI, continuous CFEs (>8 seconds, 18+/-18% 12+/-17% LA sites, respectively, P=0.02), degree fractionation (mean interval: 75.6+/-14.3 msec versus 87.3+/-16.7 msec, P=0.001), mean frequencies (6.92+/-0.88 Hz 6.58+/-0.91 Hz, P=0.001) decreased Complete altered distribution toward anteroseptum, mitral annulus, appendage regions. A persistent presence vicinity sites (observed 53% patients) correlated higher procedural termination rate for CFE (63% 23%, P<0.05).Complete eliminated some CFEs. high important maintenance