Association of Imaging Markers of Myocardial Fibrosis With Metabolic and Functional Disturbances in Early Diabetic Cardiomyopathy

• DOI: 10.1161/circimaging.111.963587
• Publication Date: 2011-09-24T08:43:36Z
• Authors: Christine Jellis; Jeremy Wright; Dominic Kennedy; Julian Sacre; Carly Jenkins; Brian Haluska; Jennifer Martin; John Fenwick; Thomas H. Marwick
• Keywords: Diabetic Cardiomyopathy; Myocardial fibrosis; Association (psychology)

Metabolic and vascular disturbances contribute to diabetic cardiomyopathy, but the role of interstitial fibrosis in early disease is unproven. We sought assess relationship between imaging markers diffuse myocardial dysfunction link this possible causes cardiomyopathy.Hemodynamic metabolic data were measured 67 subjects with type 2 diabetes mellitus (age 60±10 years) no cardiac symptoms. Myocardial function was evaluated standard echocardiography deformation; ischemia excluded by exercise echocardiography. Calibrated integrated backscatter calculated from parasternal long-axis views. T1 mapping performed after contrast a modified Look-Locker technique using saturation recovery images. Amino-terminal propeptides procollagens I III, as well carboxy-terminal propeptide procollagen I, assayed determine collagen turnover. Subjects abnormal diastolic tissue velocity (E(m)) had shorter postcontrast values (P=0.042) higher calibrated (P=0.007). They heavier (P=0.003) worse capacity (P<0.001), lower insulin sensitivity (P=0.003), blunted systolic (P=0.05). Postcontrast associated (E(m) r=0.28, P=0.020; E/E(m) r=-0.24, P=0.049), impaired (r=0.30, P=0.016), central adiposity (r=-0.26, P=0.046), blood pressure (systolic r=-0.30, P=0.012; r=-0.49, P<0.001), P=0.037). The association (β=-0.31, P=0.017) independent disturbance. III linked r=-0.32, P=0.008) P=0.015) not values.The dysfunction, values, disturbance supports that an underlying contributor cardiomyopathy.