Rapid Detection of Coronary Artery Stenoses With Real-Time Perfusion Echocardiography During Regadenoson Stress

• DOI: 10.1161/circimaging.111.966341
• Publication Date: 2011-09-24T08:43:36Z
• Authors: Thomas R. Porter; Mary Adolphson; Robin R. High; Lynette M. Smith; Joan Olson; Michelle Erdkamp; Feng Xie; Edward O'Leary; Benjamin F. Wong; Susan Eifert-Rain; Mary E. Hagen; Sahar S. Abdelmoneim; Sharon L. Mulvagh
• Keywords: Regadenoson; Bolus (digestion)

Real-time myocardial contrast echocardiography permits the detection of perfusion abnormalities during stress echocardiography, which may improve accuracy test in detecting coronary artery stenoses. We hypothesized that this technique could be used after a bolus injection selective A2A receptor agonist regadenoson to rapidly and safely detect stenoses.In 100 patients referred for quantitative angiography, real-time was performed continuous intravenous infusion 3% Definity at baseline 2-minute intervals up 6 minutes (400 μg). Myocardial assessed by examination replenishment brief high mechanical index impulses. A defect defined as delay (>2 seconds) 2 contiguous segments. Wall motion also analyzed. The overall sensitivity/specificity/accuracy analysis >50% diameter stenosis 80%/74%/78%, whereas wall it 60%/72%/66% (P<0.001 differences sensitivity). Sensitivity highest on images obtained first compared with motion), sensitivity 4-to-6-minute period bolus. No significant side effects occurred injection.Regadenoson appears feasible, safe, rapid noninvasive method