Preoperative Statins and Limb Salvage After Lower Extremity Revascularization in the Medicare Population

• DOI: 10.1161/circinterventions.113.000274
• Publication Date: 2013-12-04T05:06:13Z
• Authors: Todd R. Vogel; Viktor Y. Dombrov...; Edgar Luis Galiñanes; Robin L. Kruse
• Keywords: Current Procedural Terminology; Gangrene; Claudication; Critical limb ischemia; Intermittent claudication

Background— Statins stabilize atherosclerotic plaque, decrease mortality after surgical procedures, and are linked to anti-inflammatory effects. The objective of this study was evaluate preoperative administration statins longitudinal limb salvage lower extremity endovascular revascularization open surgery. Methods Results— Patients were selected from 2007 2008 Medicare claims using the International Classification Diseases, Ninth Revision, Clinical Modification , diagnosis codes for claudication (N=8128), rest pain (N=3056), ulceration/gangrene (N=11 770) Current Procedural Terminology (N=14 353) surgery (N=8601). Half 687) identified as statin users before Part D files. Amputations codes. Statin compared with nonusers had amputation rates at 30 days (11.5% versus 14.4%; P <0.0001), 90 (15.5% 19.3%; 1 year (20.9% 25.6%; <0.0001). Survival analysis demonstrated improved during ( =0.003), a similar trend =0.061), no improvement =0.65). Conclusions— Preoperative associated 1-year revascularization. strongest association found patients claudication. seem be underused among peripheral artery disease. Further evaluation use potential benefits vascular interventions is warranted.