Recurrent Mitral Regurgitation After MitraClip: Predictive Factors, Morphology, and Clinical Implication

• DOI: 10.1161/circinterventions.121.010895
• Publication Date: 2022-02-23T10:02:08Z
• Authors: Atsushi Sugiura; Refik Kavsur; Maximilian Spieker; Christos Iliadis; Tadahiro Goto; Can Öztürk; Marcel Weber; Noriaki Tabata; Sebastian Zimmer; Jan-Malte Sinning; Victor Mauri; Patrick Horn; Malte Kelm; Stephan Baldus; Georg Nickenig; Ralf Westenfeld; Roman Pfister; Marc Ulrich Becher
• Keywords: MitraClip

Recurrent mitral regurgitation (MR) following MitraClip has not been thoroughly investigated. We aimed to examine the predictive factors, morphology, and long-term outcome of recurrent MR after MitraClip.We assessed data from Heart Failure Network Rhineland registry August 2010 October 2018. Competing risk analyses were performed using Fine Gray model assess MR.Among 685 patients with a reduction in ≤2+, 61 developed within first 12 months. Flail leaflet (hazard ratio, 3.68; P=0.002) residual (MR grade 2+ versus ≤1+: hazard 2.56; P=0.03) predictors primary patients, while left atrial volume (per 10 mL increase: 1.11; P<0.001) 2.45; P=0.01) independently associated secondary patients. In loss insertion or tear predominant morphologies MR. more than half did show any disorder clip leaflets. Patients likely experience unplanned heart failure hospitalization symptom New York Association scale III/IV (54.1% 37.8%; P=0.018) undergo repeat valve intervention (9.8% 2.2%; P=0.005) during follow-up. landmark survival analysis, tended have lower (58.7% 83.9%; P=0.08) without MR.Flail larger which may be clinical outcomes MitraClip.