Cardiac Damage in Degenerative Mitral Regurgitation Treated With Transcatheter Mitral Edge-to-Edge Repair

• DOI: 10.1161/circinterventions.123.013794
• Publication Date: 2025-05-29T22:16:03Z
• Authors: Atsushi Sugiura; Masanori Yamamoto; Mike Saji; Masahiko Asami; Yusuke Enta; Masaki Nakashima; Shinichi Shirai; Masaki Izumo; Shingo Mizuno; Yusuke Watanabe; Makoto Amaki; Kazuhisa Kodama; Junichi Yamaguchi; Yoshifumi Nakajima; Toru Naganuma; Hiroki Bota; Yohei Ohno; Masahiro Yamawaki; Hiroshi Ueno; Kazuki Mizutani; Yuya Adachi; Toshiaki Otsuka; Shunsuke Kubo; Georg Nickenig; Kentaro Hayashida
• Keywords: Functional mitral regurgitation; MitraClip

BACKGROUND: The extent of cardiac damage and its association with clinical outcomes in patients undergoing transcatheter edge-to-edge repair (TEER) for degenerative mitral regurgitation remains unclear. This study was aimed to investigate treated TEER outcomes. METHODS: We analyzed the Optimized Catheter Valvular Intervention-Mitral registry, which is a prospective, multicenter observational data collection Japan. subjects were classified according at baseline: no extravalvular (stage 0), mild left ventricular or atrial 1), moderate 2), right heart 3). Two-year mortality after compared using Kaplan-Meier analysis. RESULTS: Out 579 participants, 8 (1.4%) as stage 0, 76 (13.1%) 1, 319 (55.1%) 2, 176 (30.4%) 3. survival 100% 89.5% 78.9% 75.3% 3 ( P =0.013). Compared 0 2 (hazard ratio, 3.34 [95% CI, 1.03–10.81]; =0.044) 4.51 1.37–14.85]; =0.013) associated increased risk 2-year TEER. Significant reductions failure rehospitalization rate New York Heart Association functional scale observed following (both, <0.001), irrespective damage. CONCLUSIONS: Advanced an regurgitation. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: UMIN000023653.