Clinical Features and Outcomes of Childhood Dilated Cardiomyopathy

• DOI: 10.1161/circulationaha.106.635128
• Publication Date: 2006-11-21T01:49:48Z
• Authors: Piers E. F. Daubeney; Alan W. Nugent; Patty Chondros; John B. Carlin; Steven D. Colan; Michael Cheung; Andrew M. Davis; C.W. Chow; Robert G. Weintraub
• Keywords: Dilated Cardiomyopathy

Background— Despite considerable mortality, population-based prognostic factors for childhood dilated cardiomyopathy are lacking. Methods and Results— A cohort study was undertaken of all children in Australia who presented with at age 0 to 10 years between January 1, 1987, December 31, 1996. single cardiologist analyzed cardiac investigations, a pathologist histopathological material. There were 184 subjects cardiomyopathy. Positive viral identification or lymphocytic myocarditis found 30 (68.2%) 44 cases available early histology 8 9 presenting sudden death. Freedom from death transplantation 72% (95% CI, 65% 78%) 1 year after presentation 63% 55% 70%) 5 years. By proportional hazards regression analysis, risk comprised >5 (hazard ratio 5.6, 95% 2.6 12.0), familial ratio, 2.9; 1.5 5.6), lower initial fractional shortening z score per -score unit, 0.75; 0.65 0.87), failure increase during follow-up unit increase, 0.68; 0.58 0.79). At follow-up, 78 (44.6%) 175 diagnosed life have no symptoms not taking any medication. Conclusions— Early mortality is high cardiomyopathy, but the clinical status long-term survivors good. This identifies adverse events.