Effects of Normal Blood Pressure, Prehypertension, and Hypertension on Coronary Microvascular Function

• DOI: 10.1161/circulationaha.106.650747
• Publication Date: 2007-02-05T21:33:38Z
• Authors: Dogan Erdogan; Ibrahim Yildirim; Ozgur Ciftci; Ismail Ozer; Mustafa Caliskan; Hakan Gullu; Haldun Muderrisoglu
• Keywords: Prehypertension

The assessment of coronary flow reserve (CFR) by transthoracic Doppler echocardiography has recently been introduced into clinical practice, and reduced CFR suggested to be a sensitive indicator hypertensive end-organ damage; however, date, this methodology not used evaluate in subjects with prehypertension. Accordingly, the present study was designed prehypertension.We measured 40 prehypertension, 60 patients hypertension, 50 normotensive healthy volunteers using echocardiography. None had any systemic disease. Age, gender, body mass index, heart rate, lipid profiles, fasting glucose levels, hemoglobin were similar among 3 groups. significantly lower hypertension group than prehypertension control groups; addition, it (2.23+/-0.47, 2.54+/-0.48, 2.91+/-0.53, respectively). Furthermore, we found that (beta=-0.31, P<0.01) (beta=-0.57, significant predictors multivariable model adjusted for other variables. inversely correlated age (r=-0.20, P=0.01), systolic blood pressure (r=-0.51, P<0.01), diastolic (r=-0.47, high-sensitivity C-reactive protein levels (r=-0.21, left atrium diameter (r=-0.22, mitral E deceleration time (r=-0.19, P=0.02), A velocity (r=-0.27, whereas E/A ratio positively (r=0.26, P<0.01).CFR is impaired but impairment as severe hypertension.