Evaluation of Left Ventricular Filling Pressures by Doppler Echocardiography in Patients With Hypertrophic Cardiomyopathy

• DOI: 10.1161/circulationaha.107.698985
• Publication Date: 2007-11-20T02:18:32Z
• Authors: Jeffrey B. Geske; Paul Sorajja; Rick A. Nishimura; Steve R. Ommen
• Keywords: Ventricular filling

Diastolic dysfunction is a major pathophysiological abnormality in hypertrophic cardiomyopathy (HCM). Doppler echocardiographic parameters correlate with left ventricular (LV) filling pressures other diseases, but it unclear whether these findings apply to patients HCM, who have multiple complex interrelated events leading diastolic dysfunction. This study compares estimates of direct measurements atrial pressure (LAP) via catheterization 100 HCM.One hundred were symptomatic HCM (New York Heart Association class III/IV, 82%) underwent measurement early transmitral flow velocity (E) and mitral annular velocities (e') the use transthoracic echocardiography within 48 hours cardiac LAP. In subset 42 patients, performed simultaneously. Mean LAP directly correlated medial E-e' ratio overall population (r=0.44, P<0.0001) also subgroup had simultaneous studies (r=0.28, P=0.07). However, scatter was present. A calculated mean LV derived from previously described regression equation, 95% confidence limits agreement measured exceeded +/-18 mm Hg both for group studies. Similar results obtained lateral ratio. Only 1 patient defined "normal" <8.In flows modestly Given nature precise characterization an individual cannot be determined noninvasive parameters.