Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

• DOI: 10.1161/circulationaha.107.756106
• Publication Date: 2008-06-10T00:54:36Z
• Authors: Kimio Satoh; Tetsuya Matoba; Jun Suzuki; Michael R. O'Dell; Patrizia Nigro; Zhaoqiang Cui; Amy Mohan; Shi Pan; Lingli Li; Zheng-Gen Jin; Chen Yan; Jun-ichi Abe; Bradford C. Berk
• Keywords: Cypa; Knockout mouse; Intimal hyperplasia

Oxidative stress, generated by excessive reactive oxygen species, promotes cardiovascular disease. Cyclophilin A (CyPA) is a 20-kDa chaperone protein secreted from vascular smooth muscle cells (VSMCs) in response to species that stimulates VSMC proliferation and inflammatory cell migration vitro; however, the role CyPA plays function vivo remains unknown.We tested hypothesis contributes remodeling analyzing complete carotid ligation knockout mice, wild-type mice overexpress (VSMC-Tg). After ligation, expression vessels of increased dramatically was significantly greater VSMC-Tg mice. Reactive species-induced secretion mouse VSMCs correlated with intracellular expression. Intimal medial hyperplasia after 2 weeks marked decreases increases Inflammatory into intima reduced Additionally, assessed Ki67(+) less The importance for intimal thickening shown strong correlations between number both proliferating vitro.In low flow, crucial proliferation, as well accumulation, thereby regulating flow-mediated formation.