N-Terminal Pro-B-Type Natriuretic Peptide Is a Major Predictor of the Development of Atrial Fibrillation

• DOI: 10.1161/circulationaha.109.873265
• Publication Date: 2009-10-20T01:46:33Z
• Authors: Kristen K. Patton; Patrick T. Ellinor; Susan R. Heckbert; Robert H. Christe...; Christopher DeFil...; John S. Gottdiener; Richard A. Kronmal
• Keywords: Aged, 80 and over; Immunoassay; Male; Peptide Fragments; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Risk Factors; Atrial Fibrillation; Natriuretic Peptide, Brain; Prevalence; Humans; Female; Longitudinal Studies; Aged; Proportional Hazards Models

Background— Atrial fibrillation (AF), the most common cardiac rhythm abnormality, is associated with significant morbidity, mortality, and healthcare expenditures. Elevated B-type natriuretic peptide levels have been risk of heart failure, AF, mortality. Methods Results— The relation between N-terminal pro-B-type (NT-proBNP) AF was studied in 5445 Cardiovascular Health Study participants use relative regression for predicting prevalent Cox proportional hazards incident AF. NT-proBNP were strongly an unadjusted prevalence ratio 128 highest quintile (95% confidence interval, 17.9 to 913.3; P <0.001) adjusted 147 20.4 1064.3; compared lowest. After a median follow-up 10 years (maximum 16 years), there 1126 cases (a rate 2.2 per 100 person-years). highly predictive hazard 5.2 4.3 6.4; development lowest; same contrast, remained strongest predictor after adjustment extensive number covariates, including age, sex, medication use, blood pressure, echocardiographic parameters, diabetes mellitus, 4.0 3.2 5.0; <0.001). Conclusions— In community-based population older adults, remarkable independent any other previously described factor.