Effects of Red Wine and Vodka on Collateral-Dependent Perfusion and Cardiovascular Function in Hypercholesterolemic Swine

• DOI: 10.1161/circulationaha.111.082172
• Publication Date: 2012-09-10T20:34:09Z
• Authors: Louis M. Chu; Antonio D. Lassal...; Michael P. Robich; Yuhong Liu; Thomas Burgess; Roger J. Laham; Joseph D. Sweeney; Tun-Li Shen; Frank W. Sellke
• Keywords: Contractility

Moderate consumption of alcohol, particularly red wine, has been shown to decrease cardiac risk. We used a hypercholesterolemic swine model chronic ischemia examine the effects 2 alcoholic beverages on heart. Yorkshire fed high-cholesterol diet underwent left circumflex ameroid constrictor placement induce at 8 weeks age. One group (HCC, n=9) continued alone, second (HCW, n=8) was supplemented with wine (pinot noir, 12.5% 375 mL daily), and third (HCV, vodka (40% 112 daily). After 7 weeks, function measured, ischemic myocardium harvested for analysis perfusion, myocardial fibrosis, vessel function, protein expression, oxidative stress, capillary density. Platelet measured by aggregometry. Perfusion territory as microsphere injection significantly increased in both HCW HCV compared HCC rest, but only under ventricular pacing. Microvessel relaxation response adenosine 5'-diphosphate improved alone regional contractility territory, although fibrosis decreased HCV. Expression proangiogenic proteins phospho-endothelial nitric oxide synthase vascular endothelial growth factor HCV, whereas phospho-mammalian target rapamycin group. Sirt-1 downstream antioxidant phospho-FoxO1 Protein stress density There no significant difference platelet between groups. may reduce cardiovascular risk improving collateral-dependent perfusion through different mechanisms. Red offer cardioprotection related its properties.