Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction

• DOI: 10.1161/circulationaha.117.032722
• Publication Date: 2018-07-19T09:25:35Z
• Authors: Georg Fuernau; Johannes Beck; Steffen Desch; Ingo Eitel; Christian Jung; Sandra Erbs; Norman Mangner; Philipp Lurz; Karl Fengler; Alexander Jobs; Reinhard Vonthein; Suzanne de Waha-T...; Marcus Sandri; Gerhard Schuler; Holger Thiele
• Keywords: Aged, 80 and over; Male; Time Factors; Hemodynamics; Myocardial Infarction; Shock, Cardiogenic; Recovery of Function; 3. Good health; 03 medical and health sciences; Percutaneous Coronary Intervention; Treatment Outcome; 0302 clinical medicine; Hypothermia, Induced; Germany; Humans; Female; Lactic Acid; Prospective Studies; Biomarkers; Aged

Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects in patients with complicating infarction.Patients (n=40) undergoing primary percutaneous coronary intervention without classic indications underwent randomization a 1:1 fashion 24 hours or control. end point cardiac power index at hours; secondary points included other parameters and serial measurements arterial lactate.No relevant differences were observed (mild versus control: 0.41 [interquartile range, 0.31-0.52] 0.36 0.31-0.48] W/m2; P=0.50; median difference, -0.025 95% CI, -0.12 0.06). Similarly, all not statistically different. Arterial lactate levels 6, 8, 10 significantly higher group slower decline ( P interaction=0.03). There no 30-day mortality (60% 50%; hazard ratio, 1.27; 0.55-2.94; P=0.55).In randomized trial, failed show substantial beneficial effect on infarction.URL: https://www.clinicaltrials.gov . Unique identifier: NCT01890317.