Abnormal Lymphatic Sphingosine-1-Phosphate Signaling Aggravates Lymphatic Dysfunction and Tissue Inflammation

• DOI: 10.1161/circulationaha.123.064181
• Publication Date: 2023-08-23T09:00:30Z
• Authors: Dongeon Kim; Wen Tian; Timothy Ting-Hsua...; Menglan Xiang; Ryan Vinh; Jason Lon Chang; Shenbiao Gu; Seunghee Lee; Yu Zhu; Torrey Guan; Emilie Claire Sch...; Evan Bao; J. Brandon Dixon; Peter Kao; Junliang Pan; Stanley G. Rockson; Xinguo Jiang; Mark Robert Nicolls
• Keywords: S1PR1; Lymphangiogenesis; Lymphatic Endothelium; Sphingosine-1-phosphate receptor

Lymphedema is a global health problem with no effective drug treatment. Enhanced T-cell immunity and abnormal lymphatic endothelial cell (LEC) signaling are promising therapeutic targets for this condition. Sphingosine-1-phosphate (S1P) mediates key pathway required normal LEC function, altered S1P in LECs could lead to disease pathogenic activation. Characterizing biology relevant developing much needed therapies.