DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization

• DOI: 10.1161/circulationaha.123.066002
• Publication Date: 2023-09-18T09:00:36Z
• Authors: Paulina J. Stanczyk; Yuki Tatekoshi; Jason S. Shapiro; Krithika Nayudu; Yihan Chen; Zachary Zilber; Matthew Schipma; Adam De Jesus; Amir Mahmoodzadeh; Ashley Akrami; Hsiang-Chun Chang; Hossein Ardehali
• Keywords: Mice; Animals; Cardiomegaly; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Article; Actins; Chromatin; 3. Good health; DNA Damage

Proper nuclear organization is critical for cardiomyocyte function, because global structural remodeling of morphology and chromatin structure underpins the development progression cardiovascular disease. Previous reports have implicated a role DNA damage in cardiac hypertrophy; however, mechanism this process not well delineated. AMPK (AMP-activated protein kinase) family proteins regulates metabolism response (DDR). Here, we examine whether member family, SNRK (SNF1-related kinase), which plays metabolism, also involved hypertrophic through changes DDR properties nucleus.