Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2

• DOI: 10.1161/circulationaha.123.067517
• Publication Date: 2024-05-10T09:00:47Z
• Authors: Desheng Li; Yang Liu; Changzhu Li; Zhiwen Zhou; Kangyi Gao; Hairong Bao; Jiming Yang; Genlong Xue; Dechun Yin; Xinbo Zhao; Kewei Shen; Lingmin Zhang; Jialiang Li; Chenhong Li; Jiahui Song; Lexin Zhao; Yao Pei; Lina Xuan; Yang Zhang; Yanjie Lu; Zhi-Ren Zhang; Baofeng Yang; Yue Li; Zhenwei Pan
• Keywords: Knockout mouse

G protein-coupled receptors play a critical role in atrial fibrillation (AF). Spexin is novel ligand of galanin (GALRs). In this study, we investigated the regulation spexin and GALRs on AF underlying mechanisms.