Abstract P211: Increased Salt Intake Decreases Postprandial Energy Expenditure in Healthy Volunteers - A Randomized Clinical Study

• DOI: 10.1161/hyp.72.suppl_1.p211
• Publication Date: 2018-12-06T15:08:55Z
• Authors: Anja Mähler; Nicola Wilck; Samuel Klamer; Andras Balogh; Lars Klug; Michael Boschmann; Dominik N Müller
• Keywords: Bioelectrical Impedance Analysis; Crossover study; Resting energy expenditure

High salt intake is a potential risk factor for obesity independent of energy intake, though underlying mechanisms remain unclear. Diet-induced thermogenesis (DIT) accounts about 10% total expenditure. We hypothesized that high decreases DIT in healthy volunteers. enrolled 40 subjects (sex ratio 1:1) randomized, double-blind, placebo-controlled, parallel-group study (NCT03024567). They received either 6 g or placebo daily capsules over 14 days on top their habitual diet. Before and after the intervention, resting postprandial expenditure, ambulatory blood pressure, bioelectrical impedance analysis (BIA), food from 3-day records were obtained. Energy expenditure was measured by indirect calorimetry (canopy hood) 12h overnight fast standardized 440 kcal, high-protein meal. In both groups, 19 completed (placebo: nine men, 29 ± years, BMI 23.1 0.5 kg/m 2 ; salt: ten 32 7 23.3 0.7 ). Salt foods g/d before intervention. Resting did not change group. significantly decreased ( P = 0.049) but NS Decreased accompanied fat therefore increased carbohydrate oxidation 0.03). However, this also case < 0.0001). Surprisingly, systolic pressure four 11 placebo, respectively (both Diastolic higher seven subjects, Body composition hydration due to placebo. conclusion, moderate short-term increase thermic effect This could contribute observed weight gain populations consuming Western diet salt.