Abstract P374: 24-h Blood Pressure Profile, Non-dipping Status And Incidence Of Resistant Hypertension In Patients Randomized To Bariatric Surgery Versus Medical Therapy: The Gateway Randomized Trial

• DOI: 10.1161/hyp.72.suppl_1.p374
• Publication Date: 2018-12-06T15:08:55Z
• Authors: Carlos A Schiavon; Dimas Ikeoka; Eliana V Santucci; Renato N Santos; Lucas P Damiani; Juliana D Oliveira; Camila R Torreglosa; Angela C Bersch-F...; Tamiris A Miranda; Silvana d Barros; Hélio Halpern; Frederico L Monteiro; Ricardo V Cohen; Patricia M Noujaim; Márcio G Souza; Celso Amodeo; Luiz Bortolloto; Otávio Berwanger; Alexandre B Caval...; Luciano F Drager
• Keywords: 2. Zero hunger; 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Background: Bariatric surgery represents an effective strategy for office blood pressure (BP) reduction in obese hypertensive patients. However, no previous study evaluated the impact of bariatric surgery on 24-h BP profile, non-dipping status and incidence of resistant hypertension (RH).

Methods: This is a sub-analysis of a randomized clinical trial including hypertensive patients with grade 1 and 2 obesity, aged 18 to 65 years, using at least 2 drugs at optimal doses or >2 at moderate doses. Patients were randomly allocated to either Roux-en-Y Gastric Bypass (RYGB) with medical therapy (MT) or MT alone for 12 months. We analyzed the 24-h BP profile, non-dipping status (defined by <10% of systolic BP reduction during sleep as compared to the daytime period) and RH incidence.

Results: A total of 100 patients were included (76% female, age 43.8±9.2 years, BMI 36.9±2.7 Kg/m 2 ). The 24-h BP profile was similar at 12 months in both groups, but the RYGB group required less anti-hypertensive classes compared to the MT alone (Figure). The rate of non-dipping BP did not change significantly during the follow-up (RYGB: from 18/48 (37.5%) to 22/48 (45.8%); p=0.30; MT: from 16/33 (48.5%) to 15/33 (45.5%); p=0.80). In an exploratory analysis, the incidence of RH was similar at the baseline (RYGB 10% (5/50) and MT 16% (8/50); p=0.38). After 12 months, it changed significantly in the RYGB group: 0% (0/49) while remained stable in the MT group: 14.9% (7/47) (p<0.001).

Conclusions: RYGB significantly reduced anti-hypertensive medications while promoting similar 24-h BP profile and non-dipping BP status compared to the MT alone. RYGB may be an attractive strategy to reduce RH incidence in obese patients.