Wine Polyphenols Improve Endothelial Function in Large Vessels of Female Spontaneously Hypertensive Rats

• DOI: 10.1161/hypertensionaha.107.107672
• Publication Date: 2008-02-08T02:54:08Z
• Authors: Rocío López-Sep...; Rosario Jiménez; Miguel Romero; Maria José Zarzuelo; Manuel Sánchez; Manuel Gómez-Guz...; Félix Vargas; Francisco O’Valle; Antonio Zarzuelo; Francisco Pérez-...; Juan Duarte
• Keywords: Endothelial Dysfunction

Red wine polyphenols (RWPs) have been reported to prevent hypertension and endothelial dysfunction. Several individual RWPs exert estrogenic effects. We analyzed the possible in vivo protective effects on blood pressure function of female spontaneously hypertensive rats (SHR) its relationship with ovarian function. (40 mg/kg by gavage) were orally administered for 5 weeks. Ovariectomized showed both increased isoprostaglandin F 2α excretion aortic superoxide production reduced relaxant response acetylcholine contraction nitric oxide synthase (eNOS) inhibitor l -NAME measured aorta but similar pressure, as compared sham-operated rats. Moreover, ovariectomized eNOS expression was unchanged, whereas caveolin-1, angiotensin II receptor (AT)-1, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits p22 phox p47 In SHR, systolic urinary excretion, O 2 − production, improving endothelium-dependent SHR. These changes associated unchanged expression, caveolin-1 reduced. had no effect AT-1 overexpression found animals. All these results suggest that a chronic treatment reduces vascular dysfunction through reduction oxidative stress SHR manner independent