Pregnancy Outcome After First Trimester Use of Methyldopa

• DOI: 10.1161/hypertensionaha.117.09110
• Publication Date: 2017-05-23T00:40:37Z
• Authors: Maria Hoeltzenbein; Evelin Beck; Anne-Katrin Fietz; Juliane Wernicke; Sandra Zinke; Angela Kayser; Stephanie Padberg; Corinna Weber-Sch...; Reinhard Meister; Christof Schaefer
• Keywords: Methyldopa

Published experience on first trimester exposure to methyldopa is still limited, although it recommended as first-line treatment for hypertensive disorders in pregnancy most countries. The primary aim of this prospective observational cohort study was analyze the rate major birth defects and spontaneous abortions women with therapy chronic hypertension. Outcomes 261 pregnancies 526 comparison without hypertension reported German Embryotox pharmacovigilance institute were evaluated. exposed not significantly increased compared (3.7% versus 2.5%; adjusted odds ratio, 1.24; 95% confidence interval, 0.4-4.0). There a tendency toward higher women. risk preterm higher, weight scores lower group. Head circumferences reduced boys only. neither evidence an or increase early loss nor growth restriction head circumference sensitivity analysis comparing monotherapies metoprolol. However, methyldopa-treated confirmed. In conclusion, our does indicate teratogenic methyldopa. Further studies are needed confirm its safety clarify influence intrauterine growth.URL: https://drks-neu.uniklinik-freiburg.de/drks_web/. Unique identifier: DRKS00010502.