Platelet Secretion Defects and Acquired von Willebrand Syndrome in Patients With Ventricular Assist Devices

• DOI: 10.1161/jaha.117.006519
• Publication Date: 2018-01-14T01:10:24Z
• Authors: Ulrich Geisen; Kerstin Brehm; Georg Trummer; Michael Berchtold...; Claudia Heilmann; Friedhelm Beyersdorf; Johannes Schelling; Axel Schlagenhauf; Barbara Zieger
• Keywords: Adult; Blood Platelets; Male; Time Factors; Platelet Function Tests; Blutpumpe; 610; Hemorrhage; von Willebrand factor; Severity of Illness Index; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Germany; Prevalence; Diseases of the circulatory (Cardiovascular) system; Humans; Longitudinal Studies; Hemopump; ventricular assist device; Original Research; Aged; platelet; Heart Failure; Secretory Pathway; Willebrand-Faktor; Middle Aged; RC666-701; Case-Control Studies; Female; Heart-Assist Devices; Biomarkers

The number of implanted ventricular assist devices (VADs) has increased significantly recently. Bleeding, the most frequent complication, cannot be solely attributed to anticoagulation therapy. Acquired von Willebrand syndrome (AVWS) caused by shear stress is in VAD patients and can increase bleeding risk. HeartMate III (HM III) a novel left featuring potential improvements over II.In this study, we investigated prevalence onset AVWS 198 patients. To our knowledge, largest cohort whose longitudinal data on have been collected. We also analyzed whether less severe HM than II Because platelet dysfunction raise risk, function subset In total, 60 with heart transplants as controls were included study. ratio factor collagen binding capacity factor:antigen, multimer analyses, (especially secretion α- δ-granules) investigated. All developed AVWS. As soon was explanted, disappeared within hours. had fewer symptoms. addition, exhibited δ-granule defect.AVWS develops may device causes Platelet defects should because they risk.https://www.drks.de/drks_web. Unique identifier: DRKS00000649.