Abstract T P41: Combining Conventional MRI-DWI With Advanced Quantitative T2 Imaging For Characterizing Extent Of Infarction In Ischemic Stroke: The Heterogeneity Of The Evolving Ischemic Lesion

• DOI: 10.1161/str.46.suppl_1.tp41
• Publication Date: 2022-03-20T06:13:56Z
• Authors: Anurag Trivedi; Robert Kosior; Ajay Mahajan; Christopher d’Est...; Louis Lauzon; Richard Frayne; Philip A Barber
• Keywords: Fluid-attenuated inversion recovery; Stroke; Neurovascular bundle

Background: Cerebral ischemia causes cellular injury, involving not only neurons, but also cells of the neurovascular unit. DWI provides sensitive detection cytotoxic injury during early stages stroke onset; however, measurement free-water with quantitative T2 (qT2) is generally overlooked, and may provide important additional information about tissue properties appreciated ADC alone. Therefore, better characterization ischemic required, particularly in context future clinical trials. Methods: 21 patients were imaged within 6 hours symptom onset at 24 on a 3T MRI. qT2 mapping was performed using CPMG sequence. to maps. Volumetric analysis DWI, FLAIR images, maps combined manual threshold-based approach. Results: Ischemic lesions identified 18/21 (86%) patients. tPA and/or endovascular treatment administered 83% these (recanalization confirmed 73%). Lesions detectable baseline 16 (89%) maps, 17 (94%) 11 (61%) images; grew by median 112% while 54%. The ADC/qT2 lesion overlap 16%. larger than 72% baseline, 67% hrs. Conclusions: By combining conventional advanced imaging, we are able characterize heterogeneity infarct evolution. depicts size that often depicted ADC, which be for defining extent. complementary sequences necessary understanding injury; reliance one parameter alone would underestimate