Abstract 61: The Effect of Remote Ischemic Conditioning in Stroke Subtypes: A Subgroup Analysis From the RESIST Trial

• DOI: 10.1161/str.55.suppl_1.61
• Publication Date: 2024-02-01T10:11:28Z
• Authors: Rolf Blauenfeldt; Janne K Mortensen; Jan Valentin; David C Hess; Soeren Johnsen; Claus Simonsen; Niels Hjort; Grethe Andersen
• Keywords: Stroke; Subgroup analysis; Stroke Recovery

Introduction: Remote ischemic conditioning (RIC) is a simple and non-invasive procedure that has proved safe feasible in numerous smaller clinical trials. Still, mixed results have been found recent large randomized controlled Here we present predefined subgroup analysis of the RESIST trial on effect RIC subgroups acute stroke (AIS) whether this modified by adherence to RIC. Methods: The were defined as artery atherosclerotic disease (LAA), small vessel (SVD), cardioembolic, unknown/other/multiple/rare, based ICD-10 discharge diagnoses assigned treating physician define etiology. Acceptable treatment was at least 80% received out planned cycles. outcome used entire range (‘shift analysis’) 90-day Rankin Scale score (ordinal logistic regression). ClinicalTrials.gov:NCT03481777. Results: A total 902 patients included target population group, 466 sham 436 group. did not significantly improve functional adherent with LAA, cardioembolic or multiple/unknown etiologies. In SVD (n=94), good adherence, associated improved outcome, unadjusted OR (95% CI): 2.47 (1.01-6.02), p= 0.047. SVD, 4 (8%) group compared 0 had atrial fibrillation (AF), p=0.050. association remained significant after adjusting for AF, adjusted 2.64 (1.07-6.54), 0.035. Conclusions: AIS due who 90 days. These are encouraging but should only be hypothesis-generating future studies.