Abstract WP284: Recurrent stroke in patients with incident cryptogenic stroke and underlying malignancy: A secondary analysis of the CASPR study

• DOI: 10.1161/str.56.suppl_1.wp284
• Publication Date: 2025-01-30T10:02:02Z
• Authors: Kelsey Eklund; James Siegler; Anna Bowman; Russell Van Coeve...; Lucia Chen; Mary Penckofer; Deborah Kerrigan; Hassan Aboul-Nour; Fadi Nahab; Shadi Yaghi; Farid Khasiyev; Christina Lineback; Collin Culbertson; Richa Sharma; Anvitha Sathya; Dinesh Jillella; Yasmin Aziz; Muhammad Alvi; Franziska Herpich; Mahan Shahrivari; Cheran Elangovan; Alicia Zha; Mudassir Farooqui; Aaron Rothstein; Farhan Khan; James Brorson; Samantha Brown; Ahmad Abu Qdais; David Liebeskind; Simona Nedelcu; Thanh Nguyen; Jesse Thon; Setareh Salehi Omran
• Keywords: Stroke

Introduction: Malignancy represents an important subgroup of embolic stroke undetermined source (ESUS). We aim to compare infarct features, potential sources, and long-term outcomes in ESUS patients with without malignancy. Methods: In this pre-specified secondary analysis the Cardiac Abnormalities Stroke Prevention Recurrence (CASPR) retrospective cohort study, active cancers were identified by site investigators adjudicated as malignant if they non-squamous or non-basal cell skin cancers. compared prevalence various sources (e.g., patent foramen ovale, left ventricular dysfunction, post-stroke atrial fibrillation) among The risk recurrent stroke, major bleeding, death was evaluated using adjusted Cox proportional hazards models, accounting for age, sex, vascular factors, competing initial treatment anticoagulation versus non-anticoagulant antiplatelet) regimen. Results: Of 2201 followed over a median 564 days, 236 (10.7%) diagnosed cancer at time stroke. Patients malignancy older, more frequently hypertensive did not differ regards specific patterns cardiac sources. No difference observed composite outcome (adjusted HR 1.02, 95% CI, 0.71-1.46). Age per year 1.01-1.03), baseline severity 1.03 NIHSS point, 1.01-1.05), prior 1.68, 1.38-2.05), multi-territorial pattern 1.67, 1.33-2.08) significantly associated outcome, but not. There nominally lower rate bleeding 0.45, 0.19-1.04), higher 1.58, 1.09-2.30), no significant ischemic (p=0.31). Conclusions: had mortality when Anticoagulation independently better outcomes. Further topology factors may identify whom benefit.